| First Author | Dao MA | Year | 2000 |
| Journal | Leukemia | Volume | 14 |
| Issue | 5 | Pages | 773-6 |
| PubMed ID | 10803504 | Mgi Jnum | J:61943 |
| Mgi Id | MGI:1855804 | Doi | 10.1038/sj.leu.2401781 |
| Citation | Dao MA, et al. (2000) CD34: to select or not to select? That is the question. Leukemia 14(5):773-6 |
| abstractText | Recent evidence suggests that expression of CD34 on the cell membrane does not always correlate with stem cell activity. In the mouse, there is a highly quiescent population of stem cells that lacks CD34 expression, but has full reconstituting capacity. The current review addresses the discovery of a similar population of dormant CD34-negative human hematopoietic stem cells. This information casts some uncertainty on the benefits of CD34+ cell isolation for stem cell transplantation, until more is known about the novel CD34-negative stem cell population. Methods designed to achieve removal of specific mature blood cell lineages might prove to be most advantageous in the future. |
