| First Author | Stanfield GM | Year | 2000 |
| Journal | Mol Cell | Volume | 5 |
| Issue | 3 | Pages | 423-33 |
| PubMed ID | 10882128 | Mgi Jnum | J:61503 |
| Mgi Id | MGI:1355057 | Doi | 10.1016/s1097-2765(00)80437-2 |
| Citation | Stanfield GM, et al. (2000) The ced-8 gene controls the timing of programmed cell deaths in C. elegans. Mol Cell 5(3):423-33 |
| abstractText | Loss-of-function mutations in the gene ced-8 lead to the late appearance of cell corpses during embryonic development in C. elegans. ced-8 functions downstream of or in parallel to-the regulatory cell death gene ced-9 and may function as a cell death effector downstream of the caspase encoded by the programmed cell death killer gene ced-3. In ced-8 mutants, embryonic programmed cell death probably initiates normally but proceeds slowly. ced-8 encodes a transmembrane protein that appears to be localized to the plasma membrane. The CED-8 protein is similar to human XK, a putative membrane transport protein implicated in McLeod Syndrome, a form of hereditary neuroacanthocytosis. |
