| First Author | Nanda I | Year | 2000 |
| Journal | Cytogenet Cell Genet | Volume | 89 |
| Issue | 1-2 | Pages | 67-78 |
| PubMed ID | 10894941 | Mgi Jnum | J:63245 |
| Mgi Id | MGI:1860674 | Doi | 10.1159/000015567 |
| Citation | Nanda I, et al. (2000) Conserved synteny between the chicken Z sex chromosome and human chromosome 9 includes the male regulatory gene DMRT1: a comparative (re)view on avian sex determination. Cytogenet Cell Genet 89(1-2):67-78 |
| abstractText | Sex-determination mechanisms in birds and mammals evolved independently for more than 300 million years. Unlike mammals, sex determination in birds operates through a ZZ/ZW sex chromosome system, in which the female is the heterogametic sex. However, the molecular mechanism remains to be elucidated. Comparative gene mapping revealed that several genes on human chromosome 9 (HSA 9) have homologs on the chicken Z chromosome (GGA Z), indicating the common ancestry of large parts of GGA Z and HSA 9. Based on chromosome homology maps, we isolated a Z-linked chicken ortholog of DMRT1, which has been implicated in XY sex reversal in humans. Its location on the avian Z and within the sex-reversal region on HSA 9p suggests that DMRT1 represents an ancestral dosage-sensitive gene for vertebrate sex-determination. Z dosage may be crucial for male sexual differentiation/determination in birds. Copyright 2000 S. Karger AG, Basel. |
