| First Author | López-Coviella I | Year | 2000 |
| Journal | Science | Volume | 289 |
| Issue | 5477 | Pages | 313-6 |
| PubMed ID | 10894782 | Mgi Jnum | J:63418 |
| Mgi Id | MGI:1860989 | Doi | 10.1126/science.289.5477.313 |
| Citation | Lopez-Coviella I, et al. (2000) Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9. Science 289(5477):313-6 |
| abstractText | Bone morphogenetic proteins (BMPs) have multiple functions in the developing nervous system. A member of this family, BMP-9, was found to be highly expressed in the embryonic mouse septum and spinal cord, indicating a possible role in regulating the cholinergic phenotype. In cultured neurons, BMP-9 directly induced the expression of the cholinergic gene locus encoding choline acetyltransferase and the vesicular acetylcholine transporter and up-regulated acetylcholine synthesis. The effect was reversed upon withdrawal of BMP-9. Intracerebroventricular injection of BMP-9 increased acetylcholine levels in vivo. Although certain other BMPs also up-regulated the cholinergic phenotype in vitro, they were less effective than BMP-9. These data indicate that BMP-9 is a differentiating factor for cholinergic central nervous system neurons. |
