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Publication : Antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an autoregulatory circuit.

First Author  Ivanov IP Year  2000
Journal  Nucleic Acids Res Volume  28
Issue  17 Pages  3185-96
PubMed ID  10954585 Mgi Jnum  J:64144
Mgi Id  MGI:1888795 Doi  10.1093/nar/28.17.3185
Citation  Ivanov IP, et al. (2000) SURVEY AND SUMMARY: antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an autoregulatory circuit. Nucleic Acids Res 28(17):3185-96
abstractText  The efficiency of programmed ribosomal frameshifting in decoding antizyme mRNA is the sensor for an autoregulatory circuit that controls cellular polyamine levels in organisms ranging from the yeast Schizosaccharomyces pombe to DROSOPHILA: to mammals. Comparison of the frameshift sites and flanking stimulatory signals in many organisms now permits a reconstruction of the likely evolutionary path of the remarkably conserved mRNA sequences involved in the frameshifting.
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