First Author | Ivanov IP | Year | 2000 |
Journal | Nucleic Acids Res | Volume | 28 |
Issue | 17 | Pages | 3185-96 |
PubMed ID | 10954585 | Mgi Jnum | J:64144 |
Mgi Id | MGI:1888795 | Doi | 10.1093/nar/28.17.3185 |
Citation | Ivanov IP, et al. (2000) SURVEY AND SUMMARY: antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an autoregulatory circuit. Nucleic Acids Res 28(17):3185-96 |
abstractText | The efficiency of programmed ribosomal frameshifting in decoding antizyme mRNA is the sensor for an autoregulatory circuit that controls cellular polyamine levels in organisms ranging from the yeast Schizosaccharomyces pombe to DROSOPHILA: to mammals. Comparison of the frameshift sites and flanking stimulatory signals in many organisms now permits a reconstruction of the likely evolutionary path of the remarkably conserved mRNA sequences involved in the frameshifting. |