| First Author | Yokoyama Y | Year | 2000 |
| Journal | Cancer Res | Volume | 60 |
| Issue | 16 | Pages | 4362-5 |
| PubMed ID | 10969778 | Mgi Jnum | J:64610 |
| Mgi Id | MGI:1889702 | Citation | Yokoyama Y, et al. (2000) Effect of endostatin on spontaneous tumorigenesis of mammary adenocarcinoma in a transgenic mouse model. Cancer Res 60(16):4362-5 |
| abstractText | A transgenic mouse model was used to evaluate the effect of endostatin treatment on spontaneous tumorigenesis. In this model system, female mice develop multiple mammary adenocarcinomas and male mice develop prostate cancer. Female mice treated with mouse endostatin during a 12-15-week period showed delayed tumor development by 4-6 weeks and significantly decreased tumor burden. Furthermore, endostatin treatment reduced the number of malignant lesions per mouse. In a separate set of experiments, male mice treated with endostatin showed a survival advantage, and their life spans were prolonged by 10.5 weeks over control animals. These data demonstrate that mouse endostatin is effective in delaying spontaneous tumor development and growth. |
