| First Author | Muto G | Year | 2000 |
| Journal | Clin Immunol | Volume | 97 |
| Issue | 3 | Pages | 259-65 |
| PubMed ID | 11112365 | Mgi Jnum | J:66113 |
| Mgi Id | MGI:1927995 | Doi | 10.1006/clim.2000.4928 |
| Citation | Muto G, et al. (2000) Adjuvant-induced improvement of glucose intolerance in type 2 diabetic KK-Ay mice through interleukin-1 and tumor necrosis factor-alpha. Clin Immunol 97(3):259-65 |
| abstractText | We reported that administration of complete Freund's adjuvant (CFA) improved glucose tolerance test (GTT) results in obese diabetic KK-Ay mice. In this study, we investigated its mechanism. An injection with CFA remarkably improved GTT for more than a week in KK-Ay mice, although insulin response was not changed compared with saline controls. The hypoglycemic effect of insulin was significantly, but partially, potentiated in the CFA-treated mice compared with the controls, suggesting that CFA stimulated insulin-mediated and non-insulin-mediated glucose disposal. Improvement in the GTT with CFA was partially transferable to nontreated mice by peritoneal exudative cells, but not spleen or lymph node cells. Pretreatment with anti-interleukin (IL)-1alpha and -1beta antibodies or anti-tumor necrosis factor (TNF)-alpha antibody significantly abrogated the improvement in the GTT with CFA. The results indicate that CFA-induced improvement in glucose intolerance in KK-Ay mice was mediated at least by IL-1 and TNF-alpha. Copyright 2000 Academic Press. |
