| First Author | Korobko IV | Year | 2000 |
| Journal | Mol Gen Genet | Volume | 264 |
| Issue | 4 | Pages | 411-8 |
| PubMed ID | 11129044 | Mgi Jnum | J:66478 |
| Mgi Id | MGI:1928539 | Doi | 10.1007/s004380000293 |
| Citation | Korobko IV, et al. (2000) The MAK-V protein kinase regulates endocytosis in mouse. Mol Gen Genet 264(4):411-8 |
| abstractText | We report the cloning of a mouse cDNA encoding the MAK-V protein kinase, with a putative specificity for serine/threonine residues. The mak-v gene is transcribed in adult brain and in the mouse embryo from at least 7.5 dpc. Using the yeast two-hybrid system, we showed that MAK-V interacts with Rabaptin-5, a protein which plays an important role in endocytosis. Functional studies of the MAK-V protein suggest that it regulates endocytosis. We also constructed a human mak-v cDNA and localized the human mak-v gene at 21q22.11. Its chromosomal location suggests that mak-v could be involved in disorders of the nervous system, development or in malignancies. |
