| First Author | Boiocchi M | Year | 1975 |
| Journal | Proc Natl Acad Sci U S A | Volume | 72 |
| Issue | 5 | Pages | 1892-4 |
| PubMed ID | 168581 | Mgi Jnum | J:5560 |
| Mgi Id | MGI:54037 | Doi | 10.1073/pnas.72.5.1892 |
| Citation | Boiocchi M, et al. (1975) Genetic control of endogenous C-type virus production in pancreatic acinar cells of C57BL/He and C57BL/6J mice. Proc Natl Acad Sci U S A 72(5):1892-4 |
| abstractText | Electron microscopy revealed very active production of C-type virus particles in the pancreatic acinar cells of untreated normal adult mice of the C57BL/He strain. In C57BL/6J mice, a similar picture was observed after a single intraperitoneal injection of dexamethasone. No viruses were observed in the pancreas of untreated or dexamethasone-treated BALB/c and C3Hf mice. F1 hybrids of both C57BL strains with C3Hf mice produced viruses in the same manner and quantity as the C57BL parents, whereas hybrids with BALB/c mice were entirely negative. Approximately 50% of mice of the first backcross generation of (BALB/c times C57BL/He)F1 hybrids with C57BL/He mice were active producers of C-type particles, while the other 50% were negative. It is suggested that a regulator gene that controls C-type virus production does not function in the pancreatic cells of either C57BL strain, and that BALB/c mice can provide hybrids with an active regulator. |
