| First Author | Hartley JW | Year | 1977 |
| Journal | Proc Natl Acad Sci U S A | Volume | 74 |
| Issue | 2 | Pages | 789-92 |
| PubMed ID | 191826 | Mgi Jnum | J:27157 |
| Mgi Id | MGI:74575 | Doi | 10.1073/pnas.74.2.789 |
| Citation | Hartley JW, et al. (1977) A new class of murine leukemia virus associated with development of spontaneous lymphomas. Proc Natl Acad Sci U S A 74(2):789-92 |
| abstractText | A new type of murine leukemia virus has been detected in thymuses of leukemic and late preleukemic AKR mice, in lymphomas developing in NIH Swiss mice carrying the AKR ectopic virus-inducing loci Akv-I or Akv-2, and in the thymus of a preleukemic C58 mouse. The viruses induce focal areas of morphologic alteration in a mink lung cell line and are tentatively referred to as mink cell focus-inducing (MCF) strains. They have the host range of both xenotropic and N-tropic ecotropic murine leukemia viruses, are neutralized by antisera to both ecotropic and xenotropic viruses, and are interfered with by both viruses. They may represent a particular type of genetic recombinant which emerges during the preleukemic period in high-ecotropic-virus mouse strains, and they may play a significant role in the etiology of spontaneous lymphomas. |
