| First Author | Meruelo D | Year | 1977 |
| Journal | J Exp Med | Volume | 146 |
| Issue | 5 | Pages | 1367-79 |
| PubMed ID | 411874 | Mgi Jnum | J:5893 |
| Mgi Id | MGI:54370 | Doi | 10.1084/jem.146.5.1367 |
| Citation | Meruelo D, et al. (1977) Genetic control of cell-mediated responsiveness to an AKR tumor-associated antigen: mapping of the locus involved to the I region of the H-2 complex. J Exp Med 146(5):1367-79 |
| abstractText | The role of H-2-linked genes in controlling resistance to murine leukemia viruses has been studied by measuring the cell-mediated immune response of F1 hybrid mice (between AKR and various C3H and C57BL/10 derived, H-2 congenic strains) to an AKR tumor cell line, BW5147. The studies have shown that the ability to generate a primary or secondary cell-mediated response to an AKR tumor cell antigenic determinant is under H-2 linked control. The locus determining CML responsiveness maps in the I-J subregion. Nonresponsiveness is associated with the H-2q/k and H-2b/k hybrid genotypes, whereas responsiveness is associated with the H-2k/k homozygous genotype. Nonresponsiveness may result from (a) dominant suppression; (b) recessive responsiveness; or (c) an alternate mechanism not yet understood. This type of control may be one of several H-2-associated mechanisms of defense against virus-induced neoplasms. |
