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Publication : Immunochemical evidence for three Ia loci in the I-region of the H-2 complex.

First Author  Delovitch TL Year  1977
Journal  J Exp Med Volume  146
Issue  6 Pages  1549-60
PubMed ID  72779 Mgi Jnum  J:5895
Mgi Id  MGI:54372 Doi  10.1084/jem.146.6.1549
Citation  Delovitch TL, et al. (1977) Immunochemical evidence for three Ia loci in the I-region of the H-2 complex. J Exp Med 146(6):1549-60
abstractText  Sequential immunoprecipitation analyses of Ia antigens were performed with 125I-labeled B10, B10.A(3R), and B10.A(5R) spleen cell lysates. The results suggest the presence of one I-region associated (Ia) locus (Ia-1) in the I-A subregion. In addition, they indicate that two Ia loci map between the I-J and S regions. One locus, Ia-5, maps in the I-E subregion. The second locus, most likely Ia-3, maps in either the I-E or I-C subregion. Taken together, the data demonstrate that at least three Ia loci in the I-region of the H-2 complex code for molecules detectable by immunoprecipitation.
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