| First Author | Skow LC | Year | 1978 |
| Journal | Genetics | Volume | 90 |
| Issue | 4 | Pages | 713-24 |
| PubMed ID | 744473 | Mgi Jnum | J:6097 |
| Mgi Id | MGI:54574 | Doi | 10.1093/genetics/90.4.713 |
| Citation | Skow LC (1978) Genetic variation at a locus (TAM-1) for submaxillary gland protease in the mouse and its location on chromosome No. 7. Genetics 90(4):713-24 |
| abstractText | Electrophoretic and activity variants for a testosterone-induced esteroprotease have been discovered in submaxillary glands from inbred strains of mice. The enzyme is tentatively designated tamase [TAM-1] and the variant genetic locus is Tam-1. The alleles Tam-1a and Tam-1b determine electrophoretically distinct zones of tamase activity, while Tam-lc produces no detectable enzyme activity. Data from recombinant inbred strains and B6AF1 X B6 and B6D2F1 X B6 backcrosses established linkage of Tam-1 to glucose phosphate isomerase (Gpi-1), pink-eyed dilution [p] and beta-hemoglobin (Hbb) on chromosome 7. The gene order is Gpi-1--Tam-1--p--HBB. Analysis of congenic resistant strains indicates that Tam-1 is closely linked to the minor histocompatibility locus, H-4. TAM-1 was not cross-reactive with antisera to mouse nerve growth factor, submaxillary renin, or tamases A and D. |
