| First Author | Davis MM | Year | 1980 |
| Journal | Nature | Volume | 283 |
| Issue | 5749 | Pages | 733-9 |
| PubMed ID | 6766532 | Mgi Jnum | J:6266 |
| Mgi Id | MGI:54743 | Doi | 10.1038/283733a0 |
| Citation | Davis MM, et al. (1980) An immunoglobulin heavy-chain gene is formed by at least two recombinational events. Nature 283(5749):733-9 |
| abstractText | The events of B-cell differentiation can be reconstructed in part through an analysis of the organisation of heavy-chain gene segments in differentiated B cells. A mouse immunoglobulin alpha heavy-chain gene is composed of at least three noncontiguous germ-line DNA segments--a VH gene segment, a JH gene segment associated with the Cmu gene segment, and the C alpha gene segment. These gene segments are joined together by two distinct types of DNA rearrangements--a V-J joining and a CH switch. |
