| First Author | Mayer A | Year | 1980 |
| Journal | Proc Natl Acad Sci U S A | Volume | 77 |
| Issue | 5 | Pages | 2960-3 |
| PubMed ID | 6930679 | Mgi Jnum | J:6347 |
| Mgi Id | MGI:54823 | Doi | 10.1073/pnas.77.5.2960 |
| Citation | Mayer A, et al. (1980) Genetically dominant resistance in mice to 3-methylcholanthrene-induced lymphoma. Proc Natl Acad Sci U S A 77(5):2960-3 |
| abstractText | Mice of the RF/J strain are highly susceptible to induction of thymic lymphoma by skin painting with 3-methylcholanthrene (MCA), whereas mice of the 129/J and I/LnJ strains are resistant. Resistance was the dominant trait in F1 mice of crosses of RF with each resistant strain. Analysis of the lymphoma incidence in MCA-painted backcross populations indicated segregation of a single dominant gene for resistance in both crosses. None of these strains show inducibility of the aryl hydrocarbon hydroxylase enzyme system, a phenotype attributed to the dominant Ahb gene which is also known to influence susceptibility to MCA-induced lymphoma. The occurrence of the disease in these backcrosses was independent of the hosts' phenotype at either the H-2 or Fv-1 locus, both of which have shown an influence on susceptibility to murine leukemia virus-associated lymphoma in other experimental systems. |
