| First Author | Kozak CA | Year | 1980 |
| Journal | J Exp Med | Volume | 152 |
| Issue | 1 | Pages | 219-28 |
| PubMed ID | 6249881 | Mgi Jnum | J:6358 |
| Mgi Id | MGI:54834 | Doi | 10.1084/jem.152.1.219 |
| Citation | Kozak CA, et al. (1980) Genetic mapping of xenotropic murine leukemia virus-inducing loci in five mouse strains. J Exp Med 152(1):219-28 |
| abstractText | A single mendelian gene was identified for induction of the endogenous xenotropic murine leukemia virus in five mouse strains (C57BL/10, C57L, C57BR, AKR, and BALB/c). This locus, designated Bxv-1, mapped to the same site on chromosome 1 in all strains: Id-1-Pep-3-[Bxv-1-Lp]. Thus, inducibility loci for xenotropic virus are more limited in number and chromosomal distribution than ecotropic inducibility loci. Virus expression in mice with Bxv-1 was induced by treatment of fibroblasts with 5-iododeoxyuridine or by exposure of spleen cells to a B cell mitogen, bacterial lipopolysaccharide. An analysis of the hamster X mouse somatic cell hybrids indicated that chromosome 1, alone, was sufficient for virus induction. |
