| First Author | Daniel WL | Year | 1981 |
| Journal | Biochem Genet | Volume | 19 |
| Issue | 3-4 | Pages | 211-25 |
| PubMed ID | 7247931 | Mgi Jnum | J:6529 |
| Mgi Id | MGI:55005 | Doi | 10.1007/BF00504268 |
| Citation | Daniel WL, et al. (1981) Murine liver arylsulfatase B processing influenced by region on chromosome 17. Biochem Genet 19(3-4):211-25 |
| abstractText | SM/J liver arylsulfatase B has a more rapid electrophoretic mobility and occurs as a series of more acidic isozymes following electrofocusing in narrow pH gradients than the liver enzyme from C57Bl/6J mice. The SM/J and C57BL/6J electrofocusing patterns were both converted to a single isozyme with similar isoelectric points by pretreatment with neuraminidase, suggesting that the SM/J and C57BL/6J isozymes differed with respect to their sialic acid content. Arylsulfatase B electrofocusing and thermostability phenotypes segregated independently among progeny of SM/J x C57BL/6J crosses, suggesting that the electrofocusing phenotypes were not determined by different alleles at As-1, the putative structural locus for arylsulfatase B. Comparison of the joint segregation of hepatic acid phosphatase electrophoretic patterns and liver arylsulfatase B electrofocusing profiles revealed that the electrofocusing profiles may be determined by a region on chromosome 17 near of identical to Apl. Kidney, brain, and spleen arylsulfatase B electrofocusing patterns did not appear to differ between SM/J and C57BL/6J mice. |
