| First Author | Timms GP | Year | 1981 |
| Journal | Genetics | Volume | 97 |
| Issue | 2 | Pages | 327-36 |
| PubMed ID | 7274657 | Mgi Jnum | J:6570 |
| Mgi Id | MGI:55045 | Doi | 10.1093/genetics/97.2.327 |
| Citation | Timms GP, et al. (1981) Genetics of aldehyde dehydrogenase isozymes in the mouse: evidence for multiple loci and localization of Ahd-2 on chromosome 19. Genetics 97(2):327-36 |
| abstractText | Electrophoretic and activity variation of the cytoplasmic isozyme of aldehyde dehydrogenase (designated AHD-B4) was observed among inbred strains and Harwell linkage-testing stocks of Mus musculus. The phenotypes are inherited in a normal Mendelian fashion, with two alleles showing co-dominant expression at a single locus (Ahd-2). The locus was shown to segregate independently of Ahd-1 (encoding the mitochondrial AHD-A2 isozymes on chromosome 4; HOLMES 1978). Linkage data of Ahd-2 with ep (pale ears), ru (ruby eyes) and bm (brachymorphic) suggest that it is localized near the centromeric end of chromosome 19. Electrophoretic evidence for a third AHD isozyme (designated AHD-Cy), which is predominantly localized in the liver microsomal fraction, is also presented. |
