| First Author | Harper ME | Year | 1981 |
| Journal | Proc Natl Acad Sci U S A | Volume | 78 |
| Issue | 7 | Pages | 4458-60 |
| PubMed ID | 7027261 | Mgi Jnum | J:6614 |
| Mgi Id | MGI:55089 | Doi | 10.1073/pnas.78.7.4458 |
| Citation | Harper ME, et al. (1981) Localization of the human insulin gene to the distal end of the short arm of chromosome 11. Proc Natl Acad Sci U S A 78(7):4458-60 |
| abstractText | The human insulin gene was mapped by hybridization in situ of 3H-labeled recombinant plasmid pHIG900 to chromosome preparations in the presence of 10% dextran sulfate. pHIG900 contains a 900-base pair insert of human genomic DNA that includes the coding region for the C peptide and intervening sequence 2. A significant percentage of hybridized cells (34%) exhibited silver grains on the distal end of the short arm (band p15) of chromosome 11. Furthermore, silver grains on this region represented 26% of all chromosomal label. These results demonstrate chromosomal localization of the human insulin gene to 11p15. |
