| First Author | Sunshine GH | Year | 1982 |
| Journal | Immunology | Volume | 45 |
| Issue | 2 | Pages | 357-63 |
| PubMed ID | 6977482 | Mgi Jnum | J:6703 |
| Mgi Id | MGI:55176 | Citation | Sunshine GH, et al. (1982) In vitro responses to the liver antigen F. Immunology 45(2):357-63 |
| abstractText | In this paper we describe the first in vitro response to the liver alloantigen F. The anti-F response serves as a valuable model for autoimmune phenomena since priming appropriate strains of mice (responders) with allogeneic but not syngeneic type F leads to autoantibody production. The in vitro system is based on the proliferation of T cells, from mice primed in vivo with F, when coincubated with splenic adherent cells (SAC) prepulsed with F in vivo. The system displays two important correlates of the in vivo antibody response to F:1.T cells from mice primed with syngeneic F do not proliferate when incubated with SAC prepulsed with syngeneic F and 2. Mice that do not make antibody responses to allo F in vivo (DBA/2) do not show in vitro proliferative responses. These findings indicate that the proliferative assay is a good in vitro model for the F response. |
