| First Author | Howard M | Year | 1982 |
| Journal | J Exp Med | Volume | 155 |
| Issue | 3 | Pages | 914-23 |
| PubMed ID | 6977612 | Mgi Jnum | J:39743 |
| Mgi Id | MGI:87596 | Doi | 10.1084/jem.155.3.914 |
| Citation | Howard M, et al. (1982) Identification of a T cell-derived b cell growth factor distinct from interleukin 2. J Exp Med 155(3):914-23 |
| abstractText | We report here a factor (B cell growth factor) found in induced supernatants of the mouse thymoma EL4 that co-stimulates with anti-IgM antibodies in short-term cultures of purified B lymphocytes to induce polyclonal B cell proliferation but not antibody-forming cell production. The factor is not mitogenic for resting B cells and interacts with anti-IgM-activated B cells in a non-H-2-restricted manner. Absorption studies and molecular weight analysis reveal the factor is distinct from interleukin 2. This factor synergises with antigen, interleukin 2, and an interleukin 2-free, B cell growth factor-free T cell supernatant that contains T cell-replacing factor to produce erythrocyte-specific plaque-forming cells in cultures of highly purified B cells. |
