| First Author | Dalla-Favera R | Year | 1982 |
| Journal | Science | Volume | 218 |
| Issue | 4573 | Pages | 686-8 |
| PubMed ID | 6291150 | Mgi Jnum | J:6890 |
| Mgi Id | MGI:55362 | Doi | 10.1126/science.6291150 |
| Citation | Dalla-Favera R, et al. (1982) Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene. Science 218(4573):686-8 |
| abstractText | Nonrandom chromosome rearrangements of chromosome 22 have been identified in different human malignancies. As a result of Southern blot hybridization of a c-sis probe to DNA's from mouse-human somatic cell hybrids, the human homolog (c-sis) of the transforming gene of simian sarcoma virus was assigned to chromosome 22. Hybrids between thymidine kinase-deficient mouse cells and human fibroblasts carrying a translocation of the region q11-qter of chromosome 22 to chromosome 17 were also analyzed. These studies demonstrate that the human c-sis gene is on region 22q11 greater than qter. |
