| First Author | Klempnauer KH | Year | 1982 |
| Journal | Cell | Volume | 31 |
| Issue | 2 Pt 1 | Pages | 453-63 |
| PubMed ID | 6297766 | Mgi Jnum | J:32354 |
| Mgi Id | MGI:79853 | Doi | 10.1016/0092-8674(82)90138-6 |
| Citation | Klempnauer KH, et al. (1982) Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogene. Cell 31(2 Pt 1):453-63 |
| abstractText | The oncogene (v-myb) of avian myeloblastosis virus and a large portion of its cellular homolog (c-myb) have been molecularly cloned and sequenced. The portion of c-myb we analyzed contains seven interspersed segments (or exons). Fusion of these exons creates a continuous nucleotide sequence that is remarkably similar to the sequence of v-myb and that potentially encodes a protein very similar to that specified by v-myb. Comparisons between the sequences of v-myb and c-myb indicate that transduction of c-myb to form v-myb probably resulted from an initial DNA rearrangement and the subsequent use of a spliced RNA as an intermediate. |
