| First Author | Schwab M | Year | 1983 |
| Journal | Nature | Volume | 303 |
| Issue | 5917 | Pages | 497-501 |
| PubMed ID | 6304530 | Mgi Jnum | J:7075 |
| Mgi Id | MGI:55546 | Doi | 10.1038/303497a0 |
| Citation | Schwab M, et al. (1983) A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells. Nature 303(5917):497-501 |
| abstractText | The cellular oncogene c-Ki-ras is amplified 30- to 60-fold in cells of the mouse adrenocortical tumour Y1. The amplified oncogene is located in double minute chromosomes and in a homogeneously staining chromosomal region, common karyotypical anomalies of tumour cells. The amounts of c-Ki-ras specific mRNA and of the protein (p21) encoded by the amplified gene are correspondingly elevated. Amplification and enhanced expression of cellular oncogenes may contribute to the genesis and/or maintenance of at least some naturally occurring tumours. |
