First Author | Meruelo D | Year | 1983 |
Journal | Proc Natl Acad Sci U S A | Volume | 80 |
Issue | 16 | Pages | 5032-6 |
PubMed ID | 6308669 | Mgi Jnum | J:7150 |
Mgi Id | MGI:55621 | Doi | 10.1073/pnas.80.16.5032 |
Citation | Meruelo D, et al. (1983) Association of endogenous viral loci with genes encoding murine histocompatibility and lymphocyte differentiation antigens. Proc Natl Acad Sci U S A 80(16):5032-6 |
abstractText | Several polymorphic DNA restriction endonuclease fragments hybridizing with xenotropic and ecotropic envelope virus probes map adjacent to minor histocompatibility and lymphocyte (H/Ly) antigen-encoding loci. Viral DNA restriction fragments are associated with Ly-17 on chromosome 1, H-30, H-3, and H-13 on chromosome 2, Ly-21 on chromosome 7, H-28 on chromosome 3, and H-38 (chromosomal location as yet undetermined). In each case no recombinant can be found between the H/Ly locus in question and the virus-related restriction fragment, suggesting that linkage is very tight. Although some viral loci map to locations where no H/Ly has yet been mapped, the frequency and tightness of linkage in the seven instances described, coupled with the large number of as yet unmapped H/Ly loci, suggests that the associations found are significant. |