| First Author | Taparowsky E | Year | 1983 |
| Journal | Cell | Volume | 34 |
| Issue | 2 | Pages | 581-6 |
| PubMed ID | 6616621 | Mgi Jnum | J:20263 |
| Mgi Id | MGI:68369 | Doi | 10.1016/0092-8674(83)90390-2 |
| Citation | Taparowsky E, et al. (1983) Structure and activation of the human N-ras gene. Cell 34(2):581-6 |
| abstractText | The normal human N-ras gene has been cloned. In structure and sequence it closely resembles the human H-ras and K-ras genes. The three genes share regions of nucleotide homology and nucleotide divergence within coding sequences and have a common intron/exon structure, indicating that they have evolved from a similarly spliced ancestral gene. The N-ras gene of SK-N-SH neuroblastoma cells has transforming activity, while the normal N-ras gene does not, the result of a single nucleotide change substituting lysine for glutamine in position 61 of the N-ras gene product. From previous studies we conclude that amino acid substitutions in two distinct regions can activate the transforming potential of ras gene products. |
