| First Author | Kelly K | Year | 1983 |
| Journal | Cell | Volume | 35 |
| Issue | 3 Pt 2 | Pages | 603-10 |
| PubMed ID | 6606489 | Mgi Jnum | J:7265 |
| Mgi Id | MGI:55736 | Doi | 10.1016/0092-8674(83)90092-2 |
| Citation | Kelly K, et al. (1983) Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell 35(3 Pt 2):603-10 |
| abstractText | We show that c-myc is an inducible gene that is regulated by specific growth signals in a cell-cycle-dependent manner. Specifically, agents that initiate the first phase of a proliferative response in lymphocytes (lipopolysaccharide or Concanavalin A) and fibroblasts (platelet-derived growth factor) induce c-myc mRNA. Within one to three hr after the addition of these mitogens to the appropriate cells, c-myc mRNA concentration is increased between 10- and 40-fold. This induction of c-myc mRNA occurs in the presence of cycloheximide and, therefore, does not require the synthesis of new protein species. Consequently, the induction of c-myc mRNA is not secondary to growth. In addition, c-myc mRNA is superinduced by the combination of cycloheximide and mitogen, a finding consistent with a model that a labile protein may regulate c-myc levels in these cells. Further, this work suggests a regulatory linkage between the function of two oncogenes--c-myc and c-sis--the latter being the putative structural gene for PDGF. |
