| First Author | Kraal G | Year | 1983 |
| Journal | Immunogenetics | Volume | 18 |
| Issue | 6 | Pages | 585-92 |
| PubMed ID | 6606619 | Mgi Jnum | J:7272 |
| Mgi Id | MGI:55743 | Doi | 10.1007/BF00345966 |
| Citation | Kraal G, et al. (1983) Genetic control of T-cell subset representation in inbred mice. Immunogenetics 18(6):585-92 |
| abstractText | Lyt-2+ T cells constitute a significantly greater proportion of the total peripheral T-cell population in C57BL mice than in BALB/c and other mouse strains. The inheritance of this differential representation of Lyt-2- vs. Lyt-2+ T cells was studied by two-color immunofluorescence analysis of peripheral T cell subsets in BALB/c, C57BL, F1 and F2 generations, and in CXB recombinant inbred strains. It was shown that the C57BL phenotype (low Lyt-2-/Lyt-2+ ratio) is a dominant Mendelian character. Studies of subpopulations of thymocytes and of early thymus emigrants indicate that the representation of mature Lyt-2- and Lyt-2+ T cells is influenced by mechanisms of selection or differential turnover in the peripheral lymphoid organs, but that thymic and prethymic influences may also play a role. |
