| First Author | Curran T | Year | 1984 |
| Journal | Cell | Volume | 36 |
| Issue | 2 | Pages | 259-68 |
| PubMed ID | 6319013 | Mgi Jnum | J:7291 |
| Mgi Id | MGI:55762 | Doi | 10.1016/0092-8674(84)90219-8 |
| Citation | Curran T, et al. (1984) Viral and cellular fos proteins: a comparative analysis. Cell 36(2):259-68 |
| abstractText | The FBJ murine osteosarcoma virus (FBJ-MuSV) induces osteosarcomas in mice and transforms fibroblasts in vitro. It contains an oncogene termed v-fos derived from a normal cellular gene by recombination with an associated helper virus. The product of the v-fos gene is a 55,000 dalton protein, p55v-fos. This protein was found in the nuclei of cells containing amplified levels of the v-fos gene, and also in the nuclei of virus-transformed cells. The c-fos protein was localized in the nuclei of normal mouse amnion cells and in the nuclei of cells transformed by a recombinant plasmid that expresses the c-fos gene product. However, p55c-fos undergoes more extensive post-translational modification in the nucleus than p55v-fos. Immunofluorescence data indicate that the level of p55c-fos in normal mouse amnion cells is similar to that found in fibroblasts transformed by the v-fos or c-fos proteins. |
