| First Author | Harris LJ | Year | 1983 |
| Journal | Nucleic Acids Res | Volume | 11 |
| Issue | 23 | Pages | 8303-15 |
| PubMed ID | 6324081 | Mgi Jnum | J:7393 |
| Mgi Id | MGI:55864 | Doi | 10.1093/nar/11.23.8303 |
| Citation | Harris LJ, et al. (1983) c-myc Gene rearrangements involving gamma immunoglobulin heavy chain gene switch regions in murine plasmacytomas. Nucleic Acids Res 11(23):8303-15 |
| abstractText | In murine plasmacytomas, the c-myc gene has frequently been found to undergo rearrangement by virtue of a T(12;15) chromosome translocation. The immunoglobulin heavy chain gene switch region (S alpha) constitutes the target for most of these recombinations particularly in IgA producing plasmacytomas. We sought to identify non-S alpha myc target sites in several IgG producing tumors. The c-myc target in MPC-11 (a BALB/c IgG2b producing plasmacytoma) has been cloned, localized to the Igh-C locus and identified as the gamma 2a heavy chain gene switch region (S gamma 2a). Furthermore, by Southern blot hybridization, we have determined that the S gamma 2b region is the c-myc target in two NZB IgG2b producing plasmacytomas. The potential relation between Ig class expressed and c-myc translocation target is discussed. |
