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Publication : Y-encoded, species-specific DNA in mice: evidence that the Y chromosome exists in two polymorphic forms in inbred strains.

First Author  Lamar EE Year  1984
Journal  Cell Volume  37
Issue  1 Pages  171-7
PubMed ID  6722869 Mgi Jnum  J:7439
Mgi Id  MGI:55909 Doi  10.1016/0092-8674(84)90312-x
Citation  Lamar EE, et al. (1984) Y-encoded, species-specific DNA in mice: evidence that the Y chromosome exists in two polymorphic forms in inbred strains. Cell 37(1):171-7
abstractText  We have investigated the structure of the murine Y chromosome by first developing a novel method for specifically cloning Y-encoded DNA and then generating a library enriched for Y-specific DNA sequences. Three randomly chosen Y DNA clones were studied and found to share several interesting properties: all three are members of small Y-specific multisequence families; all three are mouse-specific; and all three probes detect Y-encoded restriction fragments that are polymorphic. Examination of polymorphic Y chromosome restriction fragments in male DNA from nine different inbred strains suggests that only two polymorphic forms of Y chromosomal DNA exist among inbred strains of mice.
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