| First Author | D'Eustachio P | Year | 1984 |
| Journal | J Exp Med | Volume | 160 |
| Issue | 3 | Pages | 827-38 |
| PubMed ID | 6088665 | Mgi Jnum | J:7556 |
| Mgi Id | MGI:56026 | Doi | 10.1084/jem.160.3.827 |
| Citation | D'Eustachio P (1984) A genetic map of mouse chromosome 12 composed of polymorphic DNA fragments. J Exp Med 160(3):827-38 |
| abstractText | Mouse chromosome 12 encodes the heavy chains of immunoglobulins (Igh), a family of T cell surface molecules, and a tumor antigen that may be homologous to immunoglobulins. To refine and extend the genetic map of this chromosome, a procedure has been developed to isolate chromosome 12-specific DNA fragments from a somatic cell hybrid carrying the chromosome on a Chinese hamster background. Five fragments have been isolated and characterized in detail. All are polymorphic, defining loci D12-1, 2, 3, 4, and 5. Using recombinant inbred mouse strains, a tentative linkage map of chromosome 12 has been worked out that incorporates these markers, the c-fos oncogene, Igh, and Pre-1/alpha 1 antitrypsin. This strategy should be applicable to any mouse chromosome or chromosomal region that can be isolated in a somatic cell hybrid. |
