| First Author | White PC | Year | 1984 |
| Journal | Nature | Volume | 312 |
| Issue | 5993 | Pages | 465-7 |
| PubMed ID | 6095106 | Mgi Jnum | J:7661 |
| Mgi Id | MGI:56130 | Doi | 10.1038/312465a0 |
| Citation | White PC, et al. (1984) Two steroid 21-hydroxylase genes are located in the murine S region. Nature 312(5993):465-7 |
| abstractText | A common inherited disorder of steroidogenesis in man, 21-hydroxylase (21-OH) deficiency, is linked to the HLA major histocompatibility complex (MHC), and is associated in particular with certain allotypes of the HLA-linked complement proteins. Recently, this disorder was demonstrated to result from a defective structural gene for the 21-OH enzyme, also termed cytochrome P-450C21. The human (HLA) and murine (H-2) MHCs are homologous in overall organization and in the structures of their component genes. To determine whether 21-OH genes are located in the H-2 complex, we have now used a bovine adrenal complementary DNA clone encoding part of 21-OH to examine a cluster of overlapping cosmid clones derived from the S region of the BALB/c mouse. We found that there are two 21-OH genes in this region, located immediately 3' to the C4 and Slp genes. |
