| First Author | Flaherty L | Year | 1985 |
| Journal | Proc Natl Acad Sci U S A | Volume | 82 |
| Issue | 5 | Pages | 1503-7 |
| PubMed ID | 2983348 | Mgi Jnum | J:7763 |
| Mgi Id | MGI:56232 | Doi | 10.1073/pnas.82.5.1503 |
| Citation | Flaherty L, et al. (1985) Characterization of a Q subregion gene in the murine major histocompatibility complex. Proc Natl Acad Sci U S A 82(5):1503-7 |
| abstractText | We have used restriction enzyme digests, Southern blot analysis, and gene transfer experiments to identify a class I gene in the Q subregion of the murine major histocompatibility complex. By comparisons of class I genes from Q congeneic strains, five restriction fragment length polymorphisms were identified. Further studies of mutant (Qa-2-) and wild-type (Qa-2+) BALB/c sublines indicated that at least part of the structural or regulatory gene controlling a Q subregion antigen resides on a 3.7-kilobase Xba I DNA fragment and is absent in all tested Qa-2- strains. The spontaneously occurring Qa-2- BALB/cBy mutant appears to have an extensive deletion in this region. The identity of this gene was confirmed by gene transfer experiments as well as by the use of a single-copy probe. |
