| First Author | Epstein R | Year | 1985 |
| Journal | J Exp Med | Volume | 161 |
| Issue | 5 | Pages | 1219-24 |
| PubMed ID | 2580936 | Mgi Jnum | J:7825 |
| Mgi Id | MGI:56294 | Doi | 10.1084/jem.161.5.1219 |
| Citation | Epstein R, et al. (1985) Genetic markers of the antigen-specific T cell receptor locus. J Exp Med 161(5):1219-24 |
| abstractText | The restriction enzyme Eco RI reveals DNA cleavage sites that serve to distinguish the gene locus believed to encode the beta subunit of the major histocompatibility complex (MHC)-restricted, antigen-specific receptor of the T cell in BALB/c mice from that of SJL/J mice. A monoclonal antibody, KJ16-133, also distinguishes BALB/c and SJL/J, because it recognizes an allotypic marker present on a cell-surface heterodimer believed to function as the MHC-restricted, antigen-specific T cell receptor. This study has shown that these two markers cosegregate in a set of BALB/c X SJL/J recombinant inbred (RI) mouse strains, permitting the conclusion that they are linked to within 3 centimorgans of each other, and to the kappa locus on chromosome 6. The tight linkage between these independently derived, totally different T cell markers substantially strengthens the argument that they characterize the MHC-restricted antigen-specific receptor of the effector T cell. |
