| First Author | Born W | Year | 1985 |
| Journal | Proc Natl Acad Sci U S A | Volume | 82 |
| Issue | 9 | Pages | 2925-9 |
| PubMed ID | 3873070 | Mgi Jnum | J:7843 |
| Mgi Id | MGI:56312 | Doi | 10.1073/pnas.82.9.2925 |
| Citation | Born W, et al. (1985) Rearrangement of T-cell receptor beta-chain genes during T-cell development. Proc Natl Acad Sci U S A 82(9):2925-9 |
| abstractText | The kinetics and order of rearrangements in the gene complex encoding T-cell-receptor beta chains were studied by Southern blot hybridization in a collection of hybridomas derived from fetal thymocytes at various stages of ontogeny (day 14 to day 17). Our results show a steady increase in the frequency of rearranged beta complexes during this period and suggest that these rearrangements occur within the thymus. beta-chain diversity region (D beta) to beta-chain joining region (J beta) joining preceded other types of rearrangements. More complex hybridization patterns consistent with fully rearranged functional beta-chain genes did not begin to accumulate until day 16, 1 day prior to significant surface expression of the receptor protein. |
