| First Author | Huebner K | Year | 1985 |
| Journal | Proc Natl Acad Sci U S A | Volume | 82 |
| Issue | 11 | Pages | 3790-3 |
| PubMed ID | 2987946 | Mgi Jnum | J:7884 |
| Mgi Id | MGI:56353 | Doi | 10.1073/pnas.82.11.3790 |
| Citation | Huebner K, et al. (1985) The alpha-spectrin gene is on chromosome 1 in mouse and man. Proc Natl Acad Sci U S A 82(11):3790-3 |
| abstractText | By using alpha-spectrin cDNA clones of murine and human origin and somatic cell hybrids segregating either mouse or human chromosomes, the gene for alpha-spectrin has been mapped to chromosome 1 in both species. This assignment of the mouse alpha-spectrin gene to mouse chromosome 1 by DNA hybridization strengthens the previous identification of the alpha-spectrin locus in mouse with the sph locus, which previously was mapped by linkage analysis to mouse chromosome 1, distal to the Pep-3 locus. By in situ hybridization to human metaphase chromosomes, the human alpha-spectrin gene has been localized to 1q22-1q25; interestingly, the locus for a non-Rh-linked form of elliptocytosis has been provisionally mapped to band 1q2 by family linkage studies. |
