| First Author | Law SW | Year | 1985 |
| Journal | Biochem Biophys Res Commun | Volume | 131 |
| Issue | 2 | Pages | 1003-12 |
| PubMed ID | 3840371 | Mgi Jnum | J:8053 |
| Mgi Id | MGI:56522 | Doi | 10.1016/0006-291x(85)91339-7 |
| Citation | Law SW, et al. (1985) Human ApoB-100 gene resides in the p23----pter region of chromosome 2. Biochem Biophys Res Commun 131(2):1003-12 |
| abstractText | Human apolipoprotein (apo) B-100 is the major apolipoprotein of low density lipoproteins (LDL) and the principal ligand for interaction with the LDL receptor. The gene for apoB-100 has been localized to the p23----pter region of chromosome 2 by filter hybridization analysis with radiolabelled apoB-100 cDNA probes and human-mouse somatic cell hybrids containing chromosome 2 translocations. Other genes at the end of the short arm of chromosome 2 include acid phosphatase, proopiomelanocortin complex, malate dehydrogenase, and N-myc, the latter gene has been previously localized to the same bands (2p23----pter) as the apoB-100 gene. The localization of the apoB-100 gene to the p23----pter region of chromosome 2 completes the genomic organizational relationship of the LDL receptor and the two apolipoprotein ligands for the LDL receptor, apoE and apoB-100; the LDL receptor and apoE having been previously localized to chromosome 19. |
