| First Author | Todokoro K | Year | 1986 |
| Journal | Biochem Biophys Res Commun | Volume | 135 |
| Issue | 3 | Pages | 1112-8 |
| PubMed ID | 3457564 | Mgi Jnum | J:8261 |
| Mgi Id | MGI:56730 | Doi | 10.1016/0006-291x(86)91043-0 |
| Citation | Todokoro K, et al. (1986) Sequential expression of proto-oncogenes during a mouse erythroleukemia cell differentiation. Biochem Biophys Res Commun 135(3):1112-8 |
| abstractText | To investigate the possible involvement of proto-oncogenes in the regulation of cell differentiation and proliferation, their transcriptional levels were measured by Northern blot analysis during the process of dimethyl sulfoxide-induced differentiation of mouse erythroleukemia cells. The differentiation into erythrocytes was accompanied by sequential transient expression of the proto-oncogenes in the order of c-fos, c-myb, c-myc and c-k-ras, during the first 48 hr of differentiation induction. Following the transient expression of these proto-oncogenes, adult type sss-globin and embryonic type yl-globin gene transcripts appeared and accumulated in terminally differentiated cells. The expression of ten other proto-oncogenes examined here were not detected, nor dramatically changed during differentiation process. |
