| First Author | Lafuse WP | Year | 1986 |
| Journal | J Exp Med | Volume | 163 |
| Issue | 6 | Pages | 1518-28 |
| PubMed ID | 3011948 | Mgi Jnum | J:20297 |
| Mgi Id | MGI:68397 | Doi | 10.1084/jem.163.6.1518 |
| Citation | Lafuse WP, et al. (1986) Mapping of a second recombination hot spot within the I-E region of the mouse H-2 gene complex. J Exp Med 163(6):1518-28 |
| abstractText | The crossover points of nine intra-I region recombinant mouse strains were determined by restriction fragment analysis. The recombinants were examined for the presence of k and p haplotype specific DNA restriction endonuclease sites. These restriction sites were a Sac I site between the E beta and E beta 2 genes, a Hpa I site within the E beta 2 gene, and a Rsa I site approximately 1 kb to the right of the E alpha gene. Seven of the recombinants were found to have crossovers between the Hpa I and the Rsa I site. This analysis suggests that a recombination hot spot exists within this segment. This segment is approximately 12-14 kb, and contains the E alpha gene and the intervening sequence between the E beta 2 and E alpha genes. |
