| First Author | Traunecker A | Year | 1986 |
| Journal | EMBO J | Volume | 5 |
| Issue | 7 | Pages | 1589-93 |
| PubMed ID | 3017705 | Mgi Jnum | J:32382 |
| Mgi Id | MGI:79880 | Doi | 10.1002/j.1460-2075.1986.tb04400.x |
| Citation | Traunecker A, et al. (1986) Normal T cell development is possible without 'functional' gamma chain genes. EMBO J 5(7):1589-93 |
| abstractText | The T cell-specific gamma gene family is organized into four V, J and C gene segments containing clusters (gamma 1, gamma 2, gamma 3, gamma 4) in germline DNA. We found that the V, J and C elements of gamma 2 are physically linked on a stretch of 6 kb of DNA while those of gamma 3 are found within a 15-kb region. Rearrangements take place only within the clusters, explaining the rigid rearrangement patterns seen in T lymphocytes. New V gamma, J gamma and C gamma gene segments were discovered and characterized allowing the better understanding of the potential germline diversity of the gamma gene family. No correlation with T cell function, i.e. cytolytic or helper, and the type of the productive gamma rearrangement could be established. In contrast we found that functional T cell clones have been able to mature without any functional gamma chain genes. |
