| First Author | Münke M | Year | 1986 |
| Journal | Cytogenet Cell Genet | Volume | 42 |
| Issue | 4 | Pages | 236-40 |
| PubMed ID | 2875852 | Mgi Jnum | J:8424 |
| Mgi Id | MGI:56891 | Doi | 10.1159/000132284 |
| Citation | Munke M, et al. (1986) The murine Hox-2 cluster of homeo box containing genes maps distal on chromosome 11 near the tail-short (Ts) locus. Cytogenet Cell Genet 42(4):236-40 |
| abstractText | Two probes derived from a mouse recombinant lambda-clone (H24.1), that contains a sequence closely homologous to the Drosophila antennapedia homeo box, were mapped to mouse chromosome (MMU) 11 by filter hybridization of somatic cell hybrid DNA. This sequence is highly homologous to a human homeo box gene (HOX2) and appears to represent one of the two genes in the Hox-2 cluster previously assigned to MMU 11. To regionally map the Hox-2 cluster, we have carried out in situ hybridization of the two H24.1 probes and of an independently isolated Hox-2 probe. The autoradiographic silver grain distributions were similar in all three experiments with a peak over band 11D. This region contains the locus for the tail-short (Ts) mutation which causes skeletal abnormalities in heterozygotes and early embryonic death in homozygotes. |
