| First Author | O'Neill AE | Year | 1986 |
| Journal | Immunogenetics | Volume | 24 |
| Issue | 6 | Pages | 368-73 |
| PubMed ID | 3025084 | Mgi Jnum | J:8531 |
| Mgi Id | MGI:56997 | Doi | 10.1007/BF00377954 |
| Citation | O'Neill AE, et al. (1986) Extensive deletions in the Q region of the mouse major histocompatibility complex. Immunogenetics 24(6):368-73 |
| abstractText | By use of Southern blot analyses and low copy number probes, the fine structure of the Q region of the mouse major histocompatibility complex was studied in more detail. With a probe recognizing the even-numbered genes Q4, Q6, and Q8, it was evident that Q4 and/or the regions flanking Q4 are polymorphic, whereas Q6 and Q8, and their flanking regions are nonpolymorphic. Perhaps the most noteworthy finding is that at least two strain haplotypes, H-2k and H-2f, possessed extensive deletions in the Q region. The most striking deletion was found in the H-2f haplotype, where the Q1 through Q9 genes appear to be missing. Because of these extensive deletions the functional importance of the Q region is questioned. |
