| First Author | Early P | Year | 1982 |
| Journal | Mol Cell Biol | Volume | 2 |
| Issue | 7 | Pages | 829-36 |
| PubMed ID | 6821506 | Mgi Jnum | J:8638 |
| Mgi Id | MGI:57103 | Doi | 10.1128/mcb.2.7.829 |
| Citation | Early P, et al. (1982) Immunoglobulin gene rearrangements in normal mouse B cells. Mol Cell Biol 2(7):829-36 |
| abstractText | We have analyzed the structure of rearranged mu heavy-chain genes obtained from the genomic DNA of normal BALB/c mouse spleen cells expressing surface immunoglobulin M. Examples were found of two types of nonproductive rearrangements, which may be responsible for allelic exclusion in normal B cells. In one of these rearrangements, a germ line D gene segment has joined to the JH4 gene segment but no V/D joining has occurred. We present evidence that D gene segments lie as a cluster between V and J gene segments in the germ line. A comparison of conserved sequences in V and D gene segments suggests that the D gene segments, which are found only in the heavy-chain gene family, may have evolved from V gene segments similar to the Vk family. |
