| First Author | Yang JN | Year | 1987 |
| Journal | Immunogenetics | Volume | 25 |
| Issue | 4 | Pages | 222-7 |
| PubMed ID | 3032783 | Mgi Jnum | J:8678 |
| Mgi Id | MGI:57143 | Doi | 10.1007/BF00404691 |
| Citation | Yang JN, et al. (1987) The endogenous retrovirus Mtv-8 on mouse chromosome 6 maps near several kappa light chain markers. Immunogenetics 25(4):222-7 |
| abstractText | Endogenous retroviruses are known to affect expression of cellular genes in the vicinity of their integration sites. The endogenous mouse mammary tumor provirus (Mtv-8) previously has been reported to reside on mouse chromosome 6 near the immunoglobulin kappa chain locus. Using pairs of mouse strains on the BALB/c (Mtv-8 positive) and C58 (Mtv-8 negative) backgrounds which are congenic for chromosome 6 genetic markers, we have confirmed the chromosome assignment of this provirus. Moreover, we have analyzed the N1 progeny of a (B6 X C58) X C58 backcross to determine the segregation of the Mtv-8 provirus with respect to polymorphisms in the Igk-VSer and Igk-J loci. The results with congenic and backcross mice together with results of others suggest that Mtv-8 is located approximately 0.52 cM from several closely linked kappa markers on chromosome 6. |
