| First Author | Rijsewijk F | Year | 1987 |
| Journal | Cell | Volume | 50 |
| Issue | 4 | Pages | 649-57 |
| PubMed ID | 3111720 | Mgi Jnum | J:28474 |
| Mgi Id | MGI:76083 | Doi | 10.1016/0092-8674(87)90038-9 |
| Citation | Rijsewijk F, et al. (1987) The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. Cell 50(4):649-57 |
| abstractText | We have isolated the Drosophila melanogaster homolog (Dint-1) of int-1, a conserved cellular oncogene implicated in viral mammary tumorigenesis in mice. The deduced Dint-1 protein sequence contains 468 amino acids and starts with a hydrophobic leader; it is 54% identical to the int-1 sequence, and all 23 cysteine residues are conserved. The putative Drosophila protein has an extra sequence of 85 amino acids, encoded on an additional exon. Dint-1 is expressed throughout development, but transcripts are barely detectable in adult flies. Hybridization in situ to embryos reveals a segmented pattern of expression. We show that Dint-1 and the segment polarity gene wingless are identical and map to the same location. The sequence of the gene suggests that the Dint-1/wingless protein functions in morphogenesis as a signal in cell-cell communication. |
