First Author | Martinsson T | Year | 1987 |
Journal | Cytogenet Cell Genet | Volume | 45 |
Issue | 2 | Pages | 99-101 |
PubMed ID | 2887402 | Mgi Jnum | J:8818 |
Mgi Id | MGI:57283 | Doi | 10.1159/000132437 |
Citation | Martinsson T, et al. (1987) Localization of the multidrug resistance-associated 170 kDa P-glycoprotein gene to mouse chromosome 5 and to homogeneously staining regions in multidrug-resistant mouse cells by in situ hybridization. Cytogenet Cell Genet 45(2):99-101 |
abstractText | This report describes the localization of the 170 kDa P-glycoprotein gene(s) to mouse chromosome 5, subbands A2 or A3. Overproduction of P-glycoprotein is associated with multidrug resistance (MDR). MDR cell lines derived from the SEWA mouse tumor carry multiple copies of the P-glycoprotein gene. These were found to reside in homogeneously staining regions, situated in different locations in different sublines. |