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Publication : Chromosomal assignments of genes for tissue plasminogen activator and urokinase in mouse.

First Author  Rajput B Year  1987
Journal  Somat Cell Mol Genet Volume  13
Issue  5 Pages  581-6
PubMed ID  2821634 Mgi Jnum  J:8866
Mgi Id  MGI:57331 Doi  10.1007/BF01534500
Citation  Rajput B, et al. (1987) Chromosomal assignments of genes for tissue plasminogen activator and urokinase in mouse. Somat Cell Mol Genet 13(5):581-6
abstractText  The genes encoding the two plasminogen activators, tissue plasminogen activator and urokinase, were mapped to mouse chromosomes using probes derived from the respective mouse cDNAs. DNA from mouse-Chinese hamster and mouse-rat somatic cell hybrids was digested with BamHI and EcoRI, respectively, and analyzed by Southern blot hybridization for the segregation of the two genes. Tissue plasminogen activator and urokinase cosegregated with mouse chromosomes 8 and 14, respectively. The plasminogen activator genes thus fall into two syntenic groups that are conserved in human and mouse.
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