| First Author | Cheng SV | Year | 1987 |
| Journal | DNA | Volume | 6 |
| Issue | 5 | Pages | 401-7 |
| PubMed ID | 2890502 | Mgi Jnum | J:8919 |
| Mgi Id | MGI:57384 | Doi | 10.1089/dna.1987.6.401 |
| Citation | Cheng SV, et al. (1987) Chromosomal localization of the mouse homolog of the Huntington's disease linked G8 (D4S10) marker. DNA 6(5):401-7 |
| abstractText | The human DNA probe G8 defines D4S10, a polymorphic locus tightly linked to the Huntington's disease gene on human chromosome 4. A subclone of G8, pSC33, showed significant cross-hybridization to discrete restriction fragments in total genomic mouse DNA. The probe detected restriction fragment length polymorphisms (RFLPs) with the enzymes Taq I and Msp I, permitting chromosomal localization of the mouse G8 homolog by linkage analysis using three sets of recombinant inbred mouse strains: BXH, BXD, and AKXD. The mouse locus was mapped to the central region of chromosome 11 at 1 centiMorgan from the SPARC gene, a locus whose human counterpart is on human chromosome 5. |
