| First Author | Cleary ML | Year | 1988 |
| Journal | J Exp Med | Volume | 167 |
| Issue | 2 | Pages | 682-7 |
| PubMed ID | 3162254 | Mgi Jnum | J:47525 |
| Mgi Id | MGI:1203722 | Doi | 10.1084/jem.167.2.682 |
| Citation | Cleary ML, et al. (1988) Chromosomal translocation involving the beta T cell receptor gene in acute leukemia. J Exp Med 167(2):682-7 |
| abstractText | DNA spanning a t(7;19) chromosomal translocation breakpoint was isolated from the human T cell line SUP-T7 established from an acute lymphoblastic leukemia. Nucleotide sequence analysis showed that the point of crossover on chromosome 7 occurred immediately adjacent to joining segment J beta 1.1 within the TCR-beta gene, suggesting that this translocation resulted from an error in TCR gene rearrangement. On chromosome 19, the translocation occurred within a previously uncharacterized transcriptional unit for which we propose the name lyl-1. An approximately 1.5-kb RNA is transcribed from this gene in a wide variety of hematolymphoid cell lines. The t(7;19) results in truncation of the lyl-1 gene and production of abnormal-sized RNAs, suggesting a role for lyl-1 in the pathogenesis of this leukemia. |
